Faculty: Siva Somasundaram
Dr. Siva Somasundaram
Director of Undergraduate Biology Studies
Associate Professor of Biology
BS., MS., PhD., Madurai Kamaraj University
Email: Click here
Sugar Land: Brazos Hall #306
Dr. Somasundaram began teaching at UH-Victoria in 2002. He has accumulated 32 years of research experience and has been teaching Biochemistry for a total of 15 years.
Dr. Somasundaram trained graduate Medical students from 1985-1990.
He was a visiting scientist at MRC-Clinical Research Center, Harrow, UK between 1990 and1992. Then he moved to Kings College, London as an Associate Clinical Biochemist, between 1992 and 1997 and established pathogenesis and prevention of nonsteroidal anti-inflammatory drugs induced intestinal inflammation. There he has applied a novel noninvasive method to study small intestinal permeability and absorptive capacity in HIV-AIDS, liver transplantation, cardiopulmonary bypass surgery and IBD patients.
He moved to University of Washington, Seattle as a senior fellow (1997-2000) and carried out the transcriptional regulation and function of ileal bile acid transporter gene in human, hamster, CFTR mice and rats by RT-PCR and immunofluorescent histochemistry. He has served as a Research Associate in the Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill (2000-2002) and contributed for the study of molecular signal transduction in apoptosis, mainly the inhibition of chemotherapy induced apoptosis of human breast cancer cell lines invitro and invivo xenograft animal model by dietary antioxidants supplements. He has also participated Phase II clinical trial research and contributed for breast cancer research. He has also been selected as NIH-sponsored regional fellow to conduct “Inside Cancer Workshops” 2009-2010.
Dr. Somasundaram has published 44 research articles in various peer reviewed journals, contributed 2 chapters in Books and presented 55 national and international conferences and meetings: (http://myprofile.cos.com/sivasoma)
Somasundaram S, Edwards C (2011) Antiarthritic Activity of Apigenin, Scutellarein and Pectinolinergenin Glycosides From Clerodendron inerme, Journal of Agricultural Science and Technology, In Press
Somasundaram S, Shuck R, Hindmarch M, Anderson P and Gunasekera R (2010) A Simple Chemical Microassay for Citrulline Measurements in Human Blood, Journal of Applied Global Research, 3 (5), 32-37
Somasundaram S, Anusuya N, Pearce K, Patil B and Manian S (2010) Molecular Target for Indigofera tinctoria Extracts on Human Breast Cancer Cell Growth Inhibition, Journal of Applied Global Research, 3 (5), 67-72
Gunasekera RS, Cokenour J, Arrambide D, Somasundaram SG (2009) Bioactive Molecules from Fruits and Vegetables Significantly Potentiate Traditional Chemotherapy, Acta Horticulturae, 841, 55-57
Somasundaram S, Pearce K, Gunasekera RS, Jayaprakasha GK, Patil B (2009) Differential phosphorylations of NFkB and Cell Growth of MDA-MB 231 Human Breast cancer Cell Line by Limonins, Acta Horticulturae, 841, 151-154
Somasundaram S, Edwards C (2009) Flavonoidal Glycosides of the Clerodendron inerme Confer Long Term Relief for Experimental Arthritis in Rats, Acta Horticulturae, 841, 403-409
Somasundaram C, Nath RK, Perkinson J, Somasundaram SG, Bjarnason (2009) NSAID-induced gut inflammation and vasoconstriction: Causes and potential reversal with beta-CGRP- A hypothesis., Bioscience Hypotheses, 2, 290-294
Ramaswamy B,, Povoski SP, Rhoades C, Allen J, Hauger M, Young D, Burak W,, Farrar W,, Yee L,, Kendra K, Somasundaram S,, Orlowski RZ, Shapiro CL (Sep 2005) Phase II trial of neoadjuvant chemotherapy with docetaxel followed by epirubicin in stage II/III breast cancer, Breast Cancer Res Treat. , 93 (1), 67-74
Small, GW Shi YY , Edmund NA, Somasundaram S, Moore DT, and Orlowski, RZ. Evidence that Mitogen-activated Protein Kinase Phosphatase-1 Induction by Proteosome Inhibitors Plays an Anti-apoptotic Role. Mol Pharmacol. 24 Sep 2004.
Small, G, Somasundaram S, Moore DT, Shi YY and Orlowski, RZ. Repression of mitogen-activated protein kinase (MAPK) phosphatase-1 by Anthracyclines contributes to their antiapoptotic activation of p44/42-MAPK. Journal of Pharmacology and Experimental Therapeutics. 307(3), 1-9. 13 Oct 2003
Somasundaram S, Edmund NA, Moore DT, Small GW, Shi YY, Orlowski RZ. Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer. Cancer Research. 62(13): 3868-75, Jul 2002<
Somasundaram S, Simpson R, Rafi S, Shergill J, Bjarnason I and Wrigglesworth J. 2, 4-Diamino-6- hydroxy pyrimidine inhibits NSAIDs induced Nitrosyl-complex EPR signals and ulcer in rat jejunum. BMC Gastroenterol. 2(1): 8, 18 Apr 2002
Stelzner M, Somasundaram S, Khakberdiev T. Systemic effects of acute terminal ileitis on uninflamed gut aggravate bile acid malabsorption. Journal of Surgical Research. 99(2): 359-64, Aug 2001
Somasundaram S. Pathogenesis of diclofenac enteropathy. Gastroenterology. 120(7): 1885; discussion 188, Jun 2001
Stelzner M, Somasundaram S, Kearney D. A simple method for measuring of intestinal solute transport in mucosal biopsy specimens. Digestive Diseases and Sciences. 46(3): 451-6, Mar 2001
Matthias Stelzner, Sivagurunathan Somasundaram, Sum P. Lee, and Rahul Kuver. Ileal mucosal bile acid absorption is increased in Cftr knockout mice. BMC Gastroenterol.. 1(1): 10, 2001